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In real practice, experienced obesity medicine providers sometimes step patients down to lower doses or extend the interval between injections after sustained goal-weight maintenance but these adjustments are clinical decisions, not patient-initiated changes

To mitigate side effects, patients should start with lower doses, gradually increasing them to allow the body to adjust

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Faster turnover requires balance

Additionally, most mechanistic studies rely on animal models, raising concerns about translatability to humans due to interspecies differences in GLP-1R distribution and signaling (Drucker, 2022)